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KMID : 1123920030170041101
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 4 p.1101 ~ p.1111
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Erythrinae Cortex inhibits Synthesis of Inflammatory Cytokines induced by IL-1 and TNF- in Cultured Human Synovial Cells
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Lee Ho
Kim Dong-Hee
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Abstract
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Our study shows that EC extract has inhibitory effect on pro-inflammatory cytokines such as TNF-α, IL-1, IL-6, iNOS and COX2 in hFLSs. IL-1β, IL-6, iNOS and COX2 mRNA expression is suppressed at a low dasage (1㎍/ml) of EC extract. TNF-α was also suppressed at higher dosages (10 ㎍/ml, 100㎍/ml). EC extract also inhibited TNF-α, IL-1β and IL-6 production in pro-inflammatory cytokine stimulated-hFLSs. Expecially IL-1β(p<0.05) production are suppressed significantly. On the other hand, EC extract did not show any cytotoxicity. Thses data suggest that EC extract has anti-inflammatory effect mostly by inhibiting IL-1β production, and thus could be used to prevent or treat some inflammatory disease such as RA. It remains to be known what are the major components responsible for anti-inflammatory effect and what is the main mechanism.
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KEYWORD
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Erythrinae Cortex, human synovial cell, pro-inflammatory cytokines
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